C03-FolfoxResponse
AI DRIVEN molecular diagnostic METHOD predicts FOLFOX response of colorectal cancer
Research method used for: FOLFOX response of stage II, III, IV colorectal cancer.
Interpretation of results: The AI method outputs a score in the range of [-1 – 1], a score > 0 predicts that a colorectal tumor sample is likely FOLFOX chemotherapy response subtype.
FOLFOX is a chemotherapy regimen that is used to treat colorectal cancer. The observed objective response to FOLFOX in metastatic colorectal cancer is ~50%. The science that formulates FOLFOX response prediction of C03-FolfoxResponse is validated in several datasets:
(a) FOLFOX treated stage 4 colorectal cancer patients with objective response: sensitivity of 97.6% and a specificity of 100%.
(b) FOLFOX treated stage 4 colorectal cancer patients: HR=2.6, pvalue=0.02(Figure 1A).
(c) FOLFOX treated epithelial-mesenchymal transition subtype stage 3 colorectal cancer patients: HR=2.36, pvalue=0.02(Figure 1B).
Figure 1A.
Figure 1B.
Sun Tian. et al., (2021) Identification of Two Subgroups of FOLFOX Resistance Patterns and Prediction of FOLFOX Response in Colorectal Cancer Patients. Cancer Investigation. DOI: 10.1080/07357907.2020.1843662. PMID: 33258714
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